中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (12): 2029-2034.doi: 10.4103/1673-5374.262570

• 综述:退行性病与再生 •    下一篇

孕酮对少突胶质细胞系的影响:所有道路都会导致黄体酮受体

  

  • 出版日期:2019-12-15 发布日期:2019-12-15

Progesterone effects on the oligodendrocyte linage: all roads lead to the progesterone receptor

Ignacio Jure 1 , Alejandro F. De Nicola 1, 2 , Florencia Labombarda 1, 2   

  1. 1 Laboratorio de Bioquímica Neuroendocrina, Instituto de Biología y Medicina Experimental, CONICET, Buenos Aires, Argentina
    2 Departamento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
  • Online:2019-12-15 Published:2019-12-15
  • Contact: Florencia Labombarda, PhD,florlabombarda@gmail.com.

摘要:

孕酮对少突胶质细胞系的影响:所有道路都会导致黄体酮受体
orcid: 0000-0001-7911-1173 (Florencia Labombarda)

Abstract:

A new role has emerged for progesterone after discovering its potent actions away from reproduction in both the central and the peripheral nervous system. The aim of the present report is to discuss progesterone’s mechanisms of action involved in myelination, remyelination and neuroinflammation. The pivotal role of the classic progesterone receptor is described and evidence is compiled about progesterone’s direct effects on oligodendrocyte linage and its indirect effects on oligodendrocyte precursor cell differentiation by decreasing the neuroinflammatory environment.

Key words: progesterone, progesterone receptor, oligodendrocyte differentiation, myelination, remyelination, neuroinflammation