中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (12): 2035-2042.doi: 10.4103/1673-5374.262571

• 综述:退行性病与再生 • 上一篇    下一篇

β淀粉样蛋白亚型在神经干细胞生物学中的生理和病理作用

  

  • 出版日期:2019-12-15 发布日期:2019-12-15

Physiological and pathological effects of amyloid-βspecies in neural stem cell biology

Adela Bernabeu-Zornoza, Raquel Coronel, Charlotte Palmer, María Monteagudo, Alberto Zambrano, Isabel Liste   

  1. Unidad de Regeneración Neural, Unidad Funcional de Investigación de Enfermedades Crónicas. Instituto de Salud Carlos III (ISCIII), Majadahonda, Madrid, Spain
  • Online:2019-12-15 Published:2019-12-15
  • Contact: Isabel Liste, PhD, iliste@isciii.es.
  • Supported by:

    This work was supported by grants from the MICINN-ISCIII (PI-10/00291 and MPY1412/09), MINECO (SAF2015-71140-R) and Comunidad de Madrid (NEUROSTEMCM consortium; S2010/BMD-2336) (all to IL).

摘要:

orcid:0000-0002-3294-9558 (Isabel Liste)

Abstract:

Although amyloid-β peptide is considered neurotoxic, it may mediate several physiological processes during embryonic development and in the adult brain. The pathological function of amyloid-β peptide has been extensively studied due to its implication in Alzheimer’s disease, but its physiological function remains poorly understood. Amyloid-β peptide can be detected in non-aggregated (monomeric) and aggregated (oligomeric and fibrillary) forms. Each form has different cytotoxic and/or physiological properties, so amyloid-β peptide and its role in Alzheimer’s disease need to be studied further. Neural stem cells and neural precursor cells are good tools for the study on neurodegenerative diseases and can provide future therapeutic applications in diseases such as Alzheimer’s disease. In this review, we provide an outline of the effects of amyloid-β peptide, in monomeric and aggregated forms, on the biology of neural stem cells/neural precursor cells, and discuss the controversies. We also describe the possible molecular targets that could be implicated in these effects, especially GSK3β. A better understanding of amyloid-β peptide (both physiological and pathological), and the signaling pathways involved are essential to advance the field of Alzheimer’s disease.

Key words: amyloid-&beta, peptide, Aβ, neural stem cells, neural progenitor cells, Alzheimer’s disease, amyloid precursor protein, toxicity, neurogenesis, gliogenesis, GSK3β