中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (12): 2079-2080.doi: 10.4103/1673-5374.262579

• 观点:周围神经损伤修复保护与再生 • 上一篇    下一篇

基于草甘膦的除草剂:周围神经系统脱髓鞘病症的危险因素?

  

  • 出版日期:2019-12-15 发布日期:2019-12-15

Glyphosate-based herbicide: a risk factor for demyelinating conditions of the peripheral nervous system?

Fabian Szepanowski, Christoph Kleinschnitz, Mark Stettner   

  1. Department of Neurology, University Medicine Essen, University Duisburg-Essen, Essen, Germany
  • Online:2019-12-15 Published:2019-12-15
  • Contact: Fabian Szepanowski, PhD, fabian.szepanowski@uni-duesseldorf.de.

摘要:

orcid: 0000-0003-2744-5416 (Fabian Szepanowski)

Abstract:

Glyphosate is a broad-spectrum herbicide originally introduced to the market in 1974 by the agrochemical company Monsanto. More than 40 years down the line, glyphosate has become one of the most economically meaningful herbicides, with a global use of more than 1.8 million pounds in 2014. In non resistant plants, glyphosate is widely believed to exert its herbicidal effect via inhibition of the 5-enolpyruvylshikimate-3-phosphate synthase, an enzyme of the shikimate pathway required for the biosynthesis of aromatic amino acids in plants and most microorganisms such as fungi, bacteria and some protozoans. As the shikimate pathway has no known physiological function in mammals, glyphosate was considered safe for humans. However, this view has been challenged by several studies conducted by researchers from various fields, leading to the assumption that agricultural spreading of glyphosate might bear health risks, including but not limited to carcinogenic, inflammatory and endocrine disruptive effects.