中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (12): 2077-2078.doi: 10.4103/1673-5374.262581

• 观点:周围神经损伤修复保护与再生 • 上一篇    下一篇

周围神经损伤啮齿动物运动功能评价的三维运动分析

  

  • 出版日期:2019-12-15 发布日期:2019-12-15

Three-dimensional motion analysis for evaluating motor function in rodents with peripheral nerve injury"

Akira Ito 1, Wang Tianshu 2, Junichi Tajino 2   

  1. 1Department of Motor Function Analysis, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan;
    2Department of Development and Rehabilitation of Motor Function, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  • Online:2019-12-15 Published:2019-12-15
  • Contact: Akira Ito, PhD, ito.akira.4m@kyoto-u.ac.jp.
  • Supported by:

    This work was supported by Japan Society for the Promotion of Science (JSPS) KAKENHI (JP17K13052, JP18H03129, and JP18K19739).

摘要:

orcid: 0000-0002-9645-9777 (Akira Ito)

Abstract:

Peripheral nerves act like networks of “wires” that conduct signals from the brain and spinal cord to organs throughout the body. Damage to these nerves leads to numbness, pain, and weakness that eventually reduces the patient’s quality of life. Fortunately, peripheral nerves have a high regenerative capacity and, in most cases, recover from mild disorders and injuries. However, there have been continuous challenges facing the development of treatments for peripheral nerve conditions such as disorders that occur through chronic mechanical stimulation like carpal tunnel syndrome, disorders due to side effects from drugs and intractable diseases like chronic inflammatory demyelinating polyneuropathy. Furthermore, self-regeneration becomes difficult when trauma causes a large gap in the axon, leading to the patient needing nerve transplantation. While autologous nerve transplantation is the current gold standard, only approximately half of the cases obtain satisfactory functional recovery. More endeavors are needed to achieve better therapeutic effect with this treatment method.