中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (12): 2091-2092.doi: 10.4103/1673-5374.262582

• 观点:退行性病与再生 • 上一篇    下一篇

神经退行性疾病中T细胞和肠道微生物群之间的交叉对话

  

  • 出版日期:2019-12-15 发布日期:2019-12-15

Cross-talk between T-cells and gut-microbiota in neurodegenerative disorders

Rodrigo Pacheco   

  1. Departamento de Ciencias Biológicas, Facultad de Ciencias de la Vida, Universidad Andres Bello, Laboratorio de Neuroinmunología, Fundación Ciencia & Vida, Ñuñoa, Santiago, Chile
  • Online:2019-12-15 Published:2019-12-15
  • Contact: Rodrigo Pacheco, PhD, rpacheco@cienciavida.org or rodrigo.pacheco@unab.cl.
  • Supported by:

    This work was supported by Programa de Apoyo a Centros con Financiamiento Basal AFB-170004 (to Fundación Ciencia & Vida) from “Comisión Nacional de Investigación Científica y Tecnológica de Chile (CONICYT)” and by grants FONDECYT-1170093 from Fondo Nacional de Desarrollo Científico y Tecnológico de Chile, MJFF-10332.01 and MJFF15076 from Michael J. Fox Foundation for Parkinson Research.

摘要:

orcid: 0000-0001-8057-9806 (Rodrigo Pacheco)

Abstract:

The emerging role of gut microbiota as a key player in the development of neurodegenerative disorders: Mammals have evolved together with commensal microbiota to establish a symbiotic relationship in which they regulate reciprocally by synthesizing and responding to several common chemical substances. In this regard, gut microbiota constitutes a consortium of bacteria that not only participates in the degradation of nutrients, but also produces metabolites, fatty acids and neurotransmitters that can act on the enzymes and receptors expressed in eukaryotic cells, which considerably affects the physiology of the host and contribute to maintaining homeostasis.