中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (1): 20-24.doi: 10.4103/1673-5374.264443

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

δ-阿片受体可作为缺血性卒中的潜在治疗靶点

  

  • 出版日期:2020-01-15 发布日期:2020-05-14

The δ-opioid Receptor as a Potential Therapeutic Target for Ischemic Stroke  

Kalpana Subedi, Hongmin Wang*   

  1. Division of Basic Biomedical Sciences and Center for Brain and Behavior Research, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA
  • Online:2020-01-15 Published:2020-05-14
  • Contact: Hongmin Wang, PhD,Hongmin.Wang@usd.edu.
  • Supported by:
    This work was supported by the National Institute of Neurological Disorders and Stroke under research grant NS088084 (to HW).

摘要: orcid: 0000-0002-0392-4458 (Hongmin Wang)

Abstract: Ischemic stroke is a global epidemic condition due to an inadequate supply of blood and oxygen to a specific area of brain either by arterial blockage or by narrowing of blood vessels. Despite having advancement in the use of thrombolytic and clot removal medicine, significant numbers of stroke patients are still left out without option for treatment. In this review, we summarize recent research work on the activation of δ-opioid receptor as a strategy for treating ischemic stroke-caused neuronal injury. Moreover, as activation of δ-opioid receptor by a non-peptidic δ-opioid receptor agonist also modulates the expression, maturation and processing of amyloid precursor protein and β-secretase activity, the potential role of these effects on ischemic stroke caused dementia or Alzheimer’s disease are also discussed.

Key words: agonist, AKT, amyloid precursor protein, BDNF, ischemic stroke, neuroprotection, δ-opioid receptor,  p38 MAPK, PI3K, TrkB