中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (1): 57-58.doi: 10.4103/1673-5374.264448

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

可塑性中的可塑性:局灶性中枢神经系统损伤引起的远端小胶质细胞经验

  

  • 出版日期:2020-01-15 发布日期:2020-05-15

The plasticity of plasticity: lesson from remote microglia induced by focal central nervous system injury

Maria Teresa Viscomi   

  1. Institute of Histology and Embriology, Università Cattolica del S. Cuore, Rome, Italy
  • Online:2020-01-15 Published:2020-05-15
  • Contact: Maria Teresa Viscomi, PhD,mariateresa.viscomi@unicatt.it.

摘要: orcid: 0000-0002-9096-4967 (Maria Teresa Viscomi)

Abstract: The last decades have represented an important season in the re-conceptualization of brain plasticity, especially in extending the concept at events occurring beyond the developmental stage and in demonstrating the profound impact of these changes on so-called spontaneous recovery after central nervous system (CNS) injuries. The study of the cellular, molecular, functional and structural mechanisms involved in brain plasticity has clearly emphasized the multitude of players engaged in this phenomenon, leading to the conceptualization that non-neuronal cells and non-neuronal mechanisms intervene in these changes and orchestrate some of the responses observed (Werner and Stevens, 2015). Among the different non-neuronal cells and non-neuronal substrates of injury-induced plasticity is becoming increasingly recognized that microglia drive a series of intrinsic CNS responses after damage (Sandvig et al., 2018; Bisicchia et al., 2019). Interestingly, the modulatory influence of microglia on brain after injury constitutes a subset of the broader brain plasticity phenomena, defined “plasticity of plasticity” (Banati, 2002). The term well describes the great capacity of microglia in modifying their morphology and their transcriptional identity in response to environment alteration/injury. The responses of microglia, like the other CNS cells, are not linear, compartmentalized, or binary, but are multifaceted, finely tuned by the extrinsic and intrinsic factors such as the nature of the stimulus, the extracellular environment and the molecular repertoire that is involved in the response and the prior state of the cells