中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (1): 67-68.doi: 10.4103/1673-5374.264458

• 观点:退行性病与再生 • 上一篇    下一篇

将脂肪酸酰胺水解酶抑制与过氧化物酶体增殖物活化受体活化相结合:一种新的潜在的多靶点治疗策略,用于治疗阿尔茨海默病

  

  • 出版日期:2020-01-15 发布日期:2020-05-15

Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease

Leonardo Brunetti, Antonio Laghezza, Fulvio Loiodice, Paolo Tortorella, Luca Piemontese#br#   

  1. Dipartimento di Farmacia - Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro”, Bari, Italy
  • Online:2020-01-15 Published:2020-05-15
  • Contact: Luca Piemontese, PhD,luca.piemontese@uniba.it.

摘要: orcid: 0000-0002-7980-5818 (Luca Piemontese)

Abstract: Alzheimer’s disease (AD) is a widespread pathology described for the first time by Aloïs Alzheimer in 1907. It can be classified as a neurodegenerative disease consisting in a progressive loss of memory and cognitive functions, whose prevalence is estimated to grow due to the increasing life expectancies all over the world. To date, the only treatments available for this disease are symptomatic and no actual effective cure is available. The main effect of the drugs commonly used in therapeutic protocols is to temporarily delay the onset of the disease and to slightly improve the patients’ cognitive capabilities