中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (3): 394-400.doi: 10.4103/1673-5374.266045

• 综述:退行性病与再生 • 上一篇    下一篇

生活方式因素和神经退行性疾病

  

  • 出版日期:2020-03-15 发布日期:2020-05-25

Dietary habits, lifestyle factors and neurodegenerative diseases

Aurel Popa-Wagner1, Dinu Iuliu Dumitrascu2, Bogdan Capitanescu3, Eugen Bogdan Petcu1, Roxana Surugiu4, Wen-Hui Fang5, Danut-Adrian Dumbrava4   

  1. 1 Griffith University School of Medicine, Gold Coast Campus, QLD, Australia
    2 Department of Anatomy, UMF “Iuliu Hatieganu”, Cluj-Napoca, Romania
    3 Department of Human Anatomy, Faculty of Medicine, University of Medicine and Pharmacy, Craiova, Romania
    4 Center of Clinical and Experimental Medicine, University of Medicine and Pharmacy, Craiova, Romania
    5 School of Healthcare Science, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK
  • Online:2020-03-15 Published:2020-05-25
  • Contact: Aurel Popa-Wagner, PhD,aurel.popa-wagner@geriatrics-healthyageing.com; Danut-Adrian Dumbrava, MD,danutdumbrava@gmail.com.

摘要: orcid: 0000-0003-4574-8605 (Aurel Popa-Wagner)

Abstract: Worldwide stroke is increasing in parallel with modernization, changes in lifestyle, and the growing elderly population. Our review is focused on the link between diet, as part of ‘modern lifestyle’, and health in the context of genetic predisposition of individuals to ‘unhealthy’ metabolic pathway activity. It is concluded that lifestyle including high sugar diets, alcohol and tobacco addiction or high fat diets as well as ageing, brain injury, oxidative stress and neuroinflammation, negatively influence the onset, severity and duration of neurodegenerative diseases. Fortunately, there are several healthy dietary components such as polyunsaturated fatty acids and the anti-oxidants curcumin, resveratrol, blueberry polyphenols, sulphoraphane, salvionic acid as well as caloric restriction and physical activity, which may counteract ageing and associated neurodegenerative diseases via increased autophagy or increased neurogenesis in the adult brain.

Key words: brain injury, dietary habits, lifestyle, metaflammation, neurodegeneration, oxidative stress, type 2 diabetes mellitus