中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (3): 453-454.doi: 10.4103/1673-5374.266055

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

局部cAMP信号在神经元生长和存活中的区室化

  

  • 出版日期:2020-03-15 发布日期:2020-05-26

Compartmentalization of local cAMP signaling in neuronal growth and survival

Tomasz Boczek1,2, Michael S. Kapiloff1   

  1. 1Department of Ophthalmology, Byers Eye Institute, Mary M. and Sash A. Spencer Center for Vision Research, Stanford University School of Medicine, Palo Alto, CA, USA 2Department of Molecular Neurochemistry, Medical University of Lodz, Poland
  • Online:2020-03-15 Published:2020-05-26
  • Contact: Michael S. Kapiloff, MD, PhD,kapiloff@stanford.edu.
  • Supported by:
    This work was supported in part by National Institutes of Health Grant EY026766 (to MSK).

摘要: orcid: 0000-0002-7005-6953 (Michael S. Kapiloff)

Abstract: Intracellular signal transduction controlling neuronal development and survival is conveyed by second messengers that are often differentially regulated over space and time. The highly polarized morphology of neurons is conferred by a network of regulatory signaling pathways that determine axon guidance and dendrite formation. Among these, cyclic adenosine monophosphate (cAMP) is a second messenger that is critical for numerous neuronal functions and known to activate and integrate a variety of downstream pathways. In the central nervous system (CNS), cAMP-dependent signaling is involved in growth cone motility, neuronal metabolism, axon extension in vitro, neuroprotection, and survival in vivo. The complexity of cAMP-dependent neuronal physiology and function raises fundamental questions about the mechanisms determining the specificity by which cAMP can regulate these processes. A growing body of evidence suggests that fidelity in cAMP signaling is often achieved by the temporal and spatial restriction of cAMP fluxes to discrete cellular compartments where cAMP diffusion is limited by phosphodiesterase-catalyzed degradation. Despite evidence showing the importance of cAMP for neuronal survival and axon pathfinding (Goldberg et al., 2002), much remains to be learned regarding the architecture supporting cAMP compartmentation in neurons.