中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (4): 625-635.doi: 10.4103/1673-5374.266910

• 综述:视神经损伤修复保护与再生 • 上一篇    下一篇

神经炎症和氧化应激协同作用促进糖尿病视觉系统中的神经变性:半乳糖凝集素-3的作用

  

  • 出版日期:2020-04-15 发布日期:2020-05-28

Neuroinflammation and oxidative stress act in concert to promote neurodegeneration in the diabetic retina and optic nerve: galectin-3 participation

Henrique Rocha Mendonça1,2,3, Raul Carpi-Santos4, Karin da Costa Calaza5, Ana Maria Blanco Martinez1   

  1. 1 Laboratório de Neurodegeneração e Reparo, Departamento de Patologia, Programa de Pós-graduação em Anatomia Patológica, Faculdade de Medicina, Hospital Universitrio Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil 2 Pólo Universitário Macaé, Unidade Integrada de Pesquisa em Produtos Bioativos e Biociências, Federal University of Rio de Janeiro, Macaé, Brazil 3 Laboratório Integrado de Morfologia, Instituto de Biodiversidade e Sustentabilidade, Núcleo de Pesquisas Ecológicas de Macaé, Federal University of Rio de Janeiro, Macaé, Brazil 4 Laboratório de Neurobiologia Celular, Instituto de Ciências Biomédicas, Centro de Ciências da Saúde, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil 5 Laboratório de Neurobiologia da Retina, Departamento de Neurobiologia, Programa de Pós-Graduação em Neurociências, Fluminense Federal University, Niterói, Brazil
  • Online:2020-04-15 Published:2020-05-28
  • Contact: Ana Maria Blanco Martinez, PhD,anamartinez@hucff.ufrj.br; Karin da Costa Calaza, PhD,kcalaza@id.uff.br.
  • Supported by:
    KCC thanks FAPERJ for the individual research fellowship. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Instituto Nacional de Ciência e Tecnologia de Neurociência Translacional (INCT-INNT) and Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)/Pensa Rio supported this work. RCS thanks FAPERJ/CAPES for the individual scholarship.

摘要:

orcid: 0000-0002-0821-5730 (Ana Maria Blanco Martinez) 

         0000-0003-1199-1826 (Karin da Costa Calaza)

Abstract: Diabetes is a lifelong disease characterized by glucose metabolic imbalance, in which low insulin levels or impaired insulin signaling lead to hyperglycemic state. Within 20 years of diabetes progression, 95% of patients will have diabetic retinopathy, the leading cause of visual defects in working-age people worldwide. Although diabetes is considered a microvascular disease, recent studies have shown that neurodegeneration precedes vascular changes within the diabetic visual system, albeit its mechanisms are still under investigation. Neuroinflammation and oxidative stress are intrinsically related phenomena, since macrophage/ microglia and astrocytes are the main sources of reactive oxygen species during central nervous system chronic degenerative diseases, and both pathological processes are increased in the visual system during diabetes. The present review will focus on recent findings of the contribution of oxidative stress derived from neuroinflammation in the early neurodegenerative aspects of the diabetic visual system and their relationship with galectin-3.

Key words: diabetes, diabetic retinopathy, galectin-3, neurodegeneration, neuroinflammation, optic nerve, oxidative stress, retina