中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (4): 653-662.doi: 10.4103/1673-5374.266911

• 综述:退行性病与再生 • 上一篇    下一篇

硫化氢在年龄相关神经退行性疾病治疗中的重要性

  

  • 出版日期:2020-04-15 发布日期:2020-05-28

Therapeutic importance of hydrogen sulfide in age-associated neurodegenerative diseases

Rubaiya Tabassum1, 2, Na Young Jeong1, 2, Junyang Jung3   

  1. 1 Department of Anatomy and Cell Biology, College of Medicine, Dong-A University, Busan, Korea
    2 Department of Medicine, Graduate School, Dong-A University, Busan, Korea
    3 Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Seoul, Korea
  • Online:2020-04-15 Published:2020-05-28
  • Contact: Na Young Jeong, MD, PhD,jnyjjy@dau.ac.kr; Junyang Jung, MD, PhD,jjung@khu.ac.kr.
  • Supported by:
    This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning, No. 2018R1A2B6001123 (to NYJ), No. 2018R1D1A1B07040282 (to JJ).

摘要:

orcid: 0000-0003-2130-4719 (Na Young Jeong) 

         0000-0003-3946-5406 (Junyang Jung)

Abstract: Hydrogen sulfide (H2S) is a gasotransmitter that acts as an antioxidant and exhibits a wide variety of cytoprotective and physiological functions in age-associated diseases. One of the major causes of age-related diseases is oxidative stress. In recent years, the importance of H2S has become clear, although its antioxidant function has not yet been fully explored. The enzymes cystathionine β-synthase, cystathionine γ-lya-se, and 3-mercaptopyruvate sulfurtransferase are involved in the enzymatic production of H2S. Previously, H2S was considered a neuromodulator, given its role in long-term hippocampal potentiation, but it is now also recognized as an antioxidant in age-related neurodegeneration. Due to aerobic metabolism, the central nervous system is vulnerable to oxidative stress in brain aging, resulting in age-associated degenerative diseases. H2S exerts its antioxidant effect by limiting free radical reactions through the activation of antioxidant enzymes, including superoxide dismutase, catalase, and glutathione peroxidase, which protect against the effects of aging by regulating apoptosis-related genes, including p53, Bax, and Bcl-2. This review explores the implications and mechanisms of H2S as an antioxidant in age-associated neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and Down syndrome.

Key words: 3-mercaptopyruvate sulfurtransferase, aging, antioxidant, cystathionine β-synthase, cystathionine γ-lyase, glutathione, hydrogen sulfide, neurodegenerative disease, oxidative stress, reactive oxygen species