中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (5): 828-837.doi: 10.4103/1673-5374.268892

• 综述:退行性病与再生 • 上一篇    下一篇

胎儿和新生动物模型中缺氧缺血性脑病的脑电图研究

  

  • 出版日期:2020-05-15 发布日期:2020-05-30

Electroencephalography studies of hypoxic ischemia in fetal and neonatal animal models

Hamid Abbasi, Charles P. Unsworth   

  1. Department of Engineering Science, the University of Auckland, Auckland, New Zealand
  • Online:2020-05-15 Published:2020-05-30
  • Contact: Charles P. Unsworth, PhD,c.unsworth@auckland.ac.nz.
  • Supported by:
    This work was supported by the Auckland Medical Research Foundation, No. 1117017 (to CPU).

摘要: orcid: 0000-0002-9153-5232 (Charles P. Unsworth)

Abstract: Alongside clinical achievements, experiments conducted on animal models (including primate or non-primate) have been effective in the understanding of various pathophysiological aspects of perinatal hypoxic/ ischemic encephalopathy (HIE). Due to the reasonably fair degree of flexibility with experiments, most of the research around HIE in the literature has been largely concerned with the neurodevelopmental outcome or how the frequency and duration of HI seizures could relate to the severity of perinatal brain injury, following HI insult. This survey concentrates on how EEG experimental studies using asphyxiated animal models (in rodents, piglets, sheep and non-human primate monkeys) provide a unique opportunity to examine from the exact time of HI event to help gain insights into HIE where human studies become difficult.

Key words: animal models, automatic detection, clinical, EEG, fetal, HIE, hypoxic-ischemic encephalopathy, neonatal, non-human primates, review, seizure