中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (5): 861-862.doi: 10.4103/1673-5374.268901

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

脑脊液神经颗粒素作为朊病毒病诊断和预后的新参与者

  


  • 出版日期:2020-05-15 发布日期:2020-05-30

Cerebrospinal fluid neurogranin as a new player in prion disease diagnosis and prognosis.

Anna Villar-Piqué1,2, Inga Zerr3,4, Franc Llorens1,2,3   

  1. 1Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Institute Carlos III, Ministry of Health, Hospitalet de Llobregat, Spain  2Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Spain  3Department of Neurology, Clinical Dementia Center and National Reference Center for CJD Surveillance, University Medical School, Göttingen, Germany  4German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany 
  • Online:2020-05-15 Published:2020-05-30
  • Contact: Anna Villar-Piqué, PhD,annavillarpique@gmail.com; Franc Llorens, PhD,franc.llorens@gmail.com.
  • Supported by:
    This work was funded by the Spanish Ministry of Health - Instituto Carlos III (Miguel Servet programme - CP/00041) to FL.

摘要:

orcid: 0000-0002-9756-7497 (Franc Llorens) 

         0000-0002-5528-208X (Anna Villar-Piqué)

Abstract: Ng is a calmodulin-binding protein mainly expressed in cerebral structures such as the cortex, hippocampus and striatum. It is mainly located in the dendritic processes, particularly in post-synaptic compartments, but also in the cytosolic compartment, being likely involved in the regulation of the intracellular calcium-calmodulin signaling pathway (Represa et al., 1990). In the last decade, a plethora of studies have demonstrated that cerebrospinal fluid (CSF) Ng is increased in AD patients and in individuals with an ADlike CSF profile (Kester et al., 2015a). This increase seems to be disease-specific because other neurodegenerative conditions including frontotemporal dementia, Lewy body dementia, Parkinson’s disease, progressive supranuclear palsy, multiple system atrophy or Huntington’s disease, present CSF Ng concentrations similar to controls (Wellington et al., 2016). Ng levels in CSF appear to be elevated in mild cognitive impairment (MCI)-affected individuals who progress to AD and are highly related to memory and cognitive function (Kester et al., 2015a; Tarawneh et al., 2016), which indicates that this protein may serve as an early AD biomarker with diagnostic utility in pre-dementia disease stages, and with prognostic utility to predict cognitive decline and MCI-to-AD conversion.