中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (5): 817-823.doi: 10.4103/1673-5374.268969

• 综述:退行性病与再生 • 上一篇    下一篇

大脑发育早期的环状RNA:对神经精神疾病发生的影响和临床意义

  

  • 出版日期:2020-05-15 发布日期:2020-05-30

Circular RNAs in early brain development and their influence and clinical significance in neuropsychiatric disorders

Chuan-Jun Zhuo1, 2, 3, Wei-Hong Hou4, 5, De-Guo Jiang2, Hong-Jun Tian3, Li-Na Wang3, Feng Jia3, Chun-Hua Zhou6, Jing-Jing Zhu2   

  1. 1 Department of Psychiatry and Genetics, School of Mental Health, Jining Medical University, Jining, Shandong Province, China
    2 Department of Psychiatry and Molecular Psychiatry, Wenzhou Seventh People’s Hospital, Wenzhou, Zhejiang Province, China
    3 Department of Psychiatry and Imaging-Genetics and Co-morbidity (PNGC-Lab), Tianjin Anding Hospital, Tianjin Mental Health Center, Mental Health Teaching Hospital, Tianjin Medical University; Department of Psychiatry, School of Basic Medical Research, Tianjin Medical University, Tianjin, China
    4 Department of Biochemistry and Molecular Biology, Medical College of Zhengzhou University, Zhengzhou, Henan Province, China
    5 Department of Biology, University of North Carolina at Charlotte, Charlotte, NC, USA
    6 Department of Pharmacy, First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
  • Online:2020-05-15 Published:2020-05-30
  • Contact: Jing-Jing Zhu, MD,chgwzm7yuan@163.com; Chun-Hua Zhou, PhD,zhouchunhua80@126.com; Chuan-Jun Zhuo, MD, PhD,chuanjunzhuotjmh@ieee.org.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, No. 81871052 (to CJZ); the Key Project of the Natural Science Foundation of Tianjin, China, No. 17JCZDJC35700 (to CJZ); the Tianjin Health Bureau Foundation of China, No. 2014KR02 (to CJZ); the Zhejiang Public Welfare Fund Project of China, No. LGF18H090002 (to DGJ); the Key Project of Wenzhou Science and Technology Bureau of China, No. ZS2017011.

摘要:

orcid: 0000-0003-1543-9000 (Chun-Hua Zhou) 

         0000-0002-3793-550X (Chuan-Jun Zhuo)

Abstract: Neuropsychiatric disorders represent a set of severe and complex mental illnesses, and the exact etiologies of which are unknown. It has been well documented that impairments in the early development of the brain contribute to the pathogenesis of many neuropsychiatric disorders. Currently, the diagnosis of neuropsychiatric disorders largely relies on subjective cognitive assessment, because there are no widely accepted biochemical or genetic biomarkers for diagnosing mental illness. Circular RNAs (circRNAs) are a novel class of endogenous non-coding RNA (ncRNA) with a closed-loop structure. In recent years, there have been tremendous advances in our understanding of the expression profiles and biological roles of circRNAs. In the brain, circRNAs are particularly enriched and are expressed more abundantly in contrast to linear counterpart transcripts. They are highly active at neuronal synapses. These features make circRNAs uniquely crucial for understanding brain health, disease, and neuropsychiatric disorders. This review focuses on the role of circRNAs in early brain development and other brain-related processes that have been associated with the development of neuropsychiatric disorders. In addition, we discuss the potential for blood or cerebrospinal fluid circRNAs to be used as novel biomarkers in the early diagnosis of neuropsychiatric disorders. The findings reviewed here may provide new insight into the pathological mechanisms underlying the onset and progression of neuropsychiatric disorders.

Key words: autism spectrum disorders, bipolar disorder, brain, exosomal circRNAs, microRNAs, nerve regeneration, non-coding RNAs, obsessive-compulsive disorders, schizophrenia