中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (5): 850-856.doi: 10.4103/1673-5374.268971

• 综述:退行性病与再生 • 上一篇    下一篇

神经退行性疾病可视为蛋白质病驱动的免疫疾病

  

  • 出版日期:2020-05-15 发布日期:2020-05-30

Neurodegenerative diseases as proteinopathies-driven immune disorders

Fausta Ciccocioppo1, 2, Giuseppina Bologna1, 2, Eva Ercolino1, 2, Laura Pierdomenico1, 2, Pasquale Simeone1, 2, Paola Lanuti1, 2#br# Damiana Pieragostino2, 3, Piero Del Boccio2, 3, Marco Marchisio1, 2, Sebastiano Miscia1, 2#br#   

  1. 1 Department of Medicine and Aging Science, University “G. d’Annunzio” of Chieti-Pescara, Chieti, Italy
    2 Centre on Aging Sciences and Translational Medicine (Ce.S.I-MeT), University “G. d’Annunzio” of Chieti-Pescara, Chieti, Italy
    3 Department of Medical, Oral and Biotechnological Sciences, University “G. d’Annunzio” of Chieti-Pescara, Chieti, Italy
  • Online:2020-05-15 Published:2020-05-30
  • Contact: Paola Lanuti, PhD,p.lanuti@unich.it.

摘要: orcid: 0000-0003-4197-9780 (Paola Lanuti)

Abstract: In the pathophysiology of neurodegenerative disorders, the role of misfolded protein deposition leading to neurodegeneration has been primarily discussed. In the last decade, however, it has been proposed a parallel involvement of innate immune activation, chronic inflammation and adaptive immunity in the neurodegeneration mechanisms triggered by proteinopathies. New insights in the neurodegenerative field strongly suggest a role for the immune system in the pathophysiology of neurodegenerative disorders. Therefore, the hypothesis underlining the modulation of the innate and the adaptive immune system in the events linked to brain deposition of misfolded proteins could open new perspectives in the setting of specific immunotherapeutic strategies for the treatment of neurodegenerative diseases. Therefore, we have reviewed the pathogenic hypothesis in neurodegenerative pathologies, underling the links between the deposition of misfolded protein mechanisms and the immune activation.

Key words: adaptive immunity, choroid plexus, immunotherapy, innate immunity, neurodegenerative diseases, neuroinflammation, proteinopathies