中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (6): 1019-1020.doi: 10.4103/1673-5374.270300

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

使用我们的迷你脑:脑类器官作为人类朊病毒病的改进细胞模型

  

  • 出版日期:2020-06-15 发布日期:2020-07-01

Using our mini-brains: cerebral organoids as an improved cellular model for human prion disease

Bradley R. Groveman, Ryan Walters, Cathryn L. Haigh   

  1. Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Division of Intramural Research, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, MT, USA
  • Online:2020-06-15 Published:2020-07-01
  • Contact: Cathryn L. Haigh, PhD,cathryn.haigh@nih.gov.
  • Supported by:
    This work was supported in part by the Intramural Research Program of the NIH, NIAID (to CLH).

摘要: orcid: 0000-0001-7591-1149 (Cathryn L. Haigh)

Abstract: Neurodegenerative diseases are an ever-increasing burden in an aging society. Currently no cure is available for any of these diseases and treatment is based on managing symptoms. Despite many candidate therapeutics demonstrating promise in animal models, none has yet shown efficacy in human trials. It is self-evident that humans are different from the animals used to model our diseases, especially models that have been highly manipulated to generate a disease in an animal that does not naturally have such a disease. These differences are likely the reason for the failures of drug candidates in human trials but, until recently, human models of neurodegenerative diseases were lacking. The development of the human cerebral organoid model, by differentiating three-dimensional human neuronal tissue from pluripotent stem cells, represents a significant advance in studying human brain diseases. Cerebral organoids have been used to model Alzheimer’s disease, Parkinson’s disease, Down’s syndrome dementia and we have now shown they can be infected with human prions creating a new model of human prion diseases.