中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (8): 1373-1376.doi: 10.4103/1673-5374.274323

• 综述:神经损伤修复保护与再生 •    下一篇

运动通过激素机制促进运动神经元损伤后的恢复

  

  • 出版日期:2020-08-15 发布日期:2020-09-15

Exercise promotes recovery after motoneuron injury via hormonal mechanisms

Cory Chew, Dale R. Sengelaub*   

  1. Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA
  • Online:2020-08-15 Published:2020-09-15
  • Contact: Dale R. Sengelaub, PhD, sengelau@indiana.edu.
  • Supported by:
    This work was supported by NIH-NINDS NS047264 to DRS.

摘要: orcid: 0000-0002-6166-8632 (Dale R. Sengelaub)

Abstract: Injuries to spinal motoneurons manifest in a variety of forms, including damage to peripheral axons, neurodegenerative disease, or direct insult centrally. Such injuries produce a variety of negative structural and functional changes in both the directly affected and neighboring motoneurons. Exercise is a relatively simple behavioral intervention that has been demonstrated to protect against, and accelerate recovery from, these negative changes. In this article, we describe how exercise is neuroprotective for motoneurons, accelerating axon regeneration following axotomy and attenuating dendritic atrophy following the death of neighboring motoneurons. In both of these injury models, the positive effects of exercise have been found to be dependent on gonadal hormone action. Here we describe a model in which exercise, hormones, and brain-derived neurotrophic factor might all interact to produce neuroprotective effects on motoneuron structure following neural injury.

Key words: axon regeneration, axotomy, dendritic morphology, exercise, hormones, neuroprotection, neurotrophins