中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (8): 1408-1416.doi: 10.4103/1673-5374.274325

• 综述:视神经损伤修复保护与再生 • 上一篇    下一篇

藏红花(Crocus Sativus L.)在眼部病理学(主要在神经变性视网膜疾病)中的有益作用:综述

  

  • 出版日期:2020-08-15 发布日期:2020-09-17

Beneficial effects of saffron (Crocus sativus L.) in ocular pathologies, particularly neurodegenerative retinal diseases

Jose A. Fernández-Albarral1, #, Rosa de Hoz1, 2, #, Ana I. Ramírez1, 2, Inés López-Cuenca1 , Elena Salobrar-García1 , María D. Pinazo-Durán4 , José M. Ramírez1, 3, * , Juan J. Salazar1, 2, *   

  1. 1 Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Madrid, Spain 2 Departamento de Inmunología, Oftalmología y ORL, Facultad de Óptica y Optometría, Madrid, Spain 3 Departamento de Inmunología, Oftalmología y ORL, Facultad de Medicina, Madrid, Spain 4 Unidad de Investigación Oftalmológica Santiago Grisolia, Universidad de Valencia, Valencia, Spain
  • Online:2020-08-15 Published:2020-09-17
  • Contact: José M. Ramírez, ramirezs@med.ucm.es; Juan J. Salazar, jjsalaza@med.ucm.es.
  • Supported by:
    This work was supported by the Ophthalmological Network OFTARED (RD16/0008/0005, RD16/0008/0022‚ of the Institute of Health of Carlos III of the Spanish Ministry of Economy; by the PN I+D+i 2008–2011, by the ISCIII-Subdirección General de Redes y Centros de Investigación Cooperativa, by the European program FEDER. SAF-2014-53779-R: from the Spanish Ministry of Economy and Competitiveness and by Articulo 83 118-2017 (UCM-Pharmactive Biotech). José A. Fernández-Albarral is currently supported by a Predoctoral Fellowship (FPU17/01023) from the Spanish Ministry of Science, Innovation, and Universities. Inés López-Cuenca is currently supported by a Predoctoral Fellowship (CT42/18-CT43/18) from the Complutense University of Madrid.

摘要:

orcid:0000-0002-5145-5094 (José M. Ramírez)

         0000-0001-5480-5902 (Juan J. Salazar)

Abstract: Saffron (Crocus sativus L.) has been traditionally used in food preparation and as a medicinal plant. It currently has numerous therapeutic properties attributed to it, such as protection against ischemia, as well as anticonvulsant, antidepressant, anxiolytic, hypolipidemic, anti-atherogenic, anti-hypertensive, antidiabetic, and anti-cancer properties. In addition, saffron has remarkable beneficial properties, such as anti-apoptotic, anti-inflammatory and antioxidant activities, due to its main metabolites, among which crocin and crocetin stand out. Furthermore, increasing evidence underwrites the possible neuroprotective role of the main bioactive saffron constituents in neurodegenerative diseases, such as Parkinson’s and Alzheimer’s diseases, both in experimental models and in clinical studies in patients. Currently, saffron supplementation is being tested for ocular neurodegenerative pathologies, such as diabetic retinopathy, retinitis pigmentosa, age-related macular degeneration and glaucoma, among others, and shows beneficial effects. The present article provides a comprehensive and up to date report of the investigations on the beneficial effects of saffron extracts on the main neurodegenerative ocular pathologies and other ocular diseases. This review showed that saffron extracts could be considered promising therapeutic agents to help in the treatment of ocular neurodegenerative diseases.

Key words: AMD, crocetin, crocin, Crocus sativus L., diabetic retinopathy, glaucoma, neuroprotection, ocular diseases, retinitis pigmentosa, saffron, safranal