中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (8): 1554-1559.doi: 10.4103/1673-5374.274346

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

自杀未遂网络成瘾青少年前额叶大脑活动异常:一项功能磁共振的评价

  

  • 出版日期:2020-08-15 发布日期:2020-09-16

Abnormal brain activity in adolescents with Internet addiction who attempt suicide: an assessment using functional magnetic resonance imaging

Yan Huang1 , Lu Xu2, * , Li Kuang3, * , Wo Wang4 , Jun Cao3 , Mu-Ni Xiao3   

  1. 1 GCP Office, Chongqing Traditional Chinese Medicine Hospital, Chongqing, China 2 Chongqing Medical and Pharmaceutical College, Chongqing, China 3 Department of Psychiatry, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China 4 Mental Health Center, University-Town Hospital of Chongqing Medical University, Chongqing, China
  • Online:2020-08-15 Published:2020-09-16
  • Contact: Li Kuang, MD, PhD, kuangli0308@163.com; Lu Xu, PhD, 106334600@qq.com.

Abstract: Internet addiction is associated with an increased risk of suicidal behavior and can lead to brain dysfunction among adolescents. However, whether brain dysfunction occurs in adolescents with Internet addiction who attempt suicide remains unknown. This observational cross-sectional study enrolled 41 young Internet addicts, aged from 15 to 20 years, from the Department of Psychiatry, the First Affiliated Hospital of Chongqing Medical University, China from January to May 2018. The participants included 21 individuals who attempted suicide and 20 individuals with Internet addiction without a suicidal attempt history. Brain images in the resting state were obtained by a 3.0 T magnetic resonance imaging scanner. The results showed that activity in the gyrus frontalis inferior of the right pars triangularis and the right pars opercularis was significantly increased in the suicidal attempt group compared with the non-suicidal attempt group. In the resting state, the prefrontal lobe of adolescents who had attempted suicide because of Internet addiction exhibited functional abnormalities, which may provide a new basis for studying suicide pathogenesis in Internet addicts. The study was authorized by the Ethics Committee of Chongqing Medical University, China (approval No. 2017 Scientific Research Ethics (2017-157)) on December 11, 2017.

Key words: adolescents, amplitude of low-frequency fluctuation, brain activity, functional magnetic resonance imaging, Internet addiction, prefrontal lobe, resting state, suicidal attempt