中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (10): 1792-1798.doi: 10.4103/1673-5374.280300

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

绿茶儿茶素和小胶质细胞功能

  

  • 出版日期:2020-10-15 发布日期:2020-08-04

Green tea catechins inhibit microglial activation which prevents the development of neurological disorders

Tahereh Farkhondeh1, Ali Mohammad Pourbagher-Shahri2, Milad Ashrafizadeh3, Silvia Llorens Folgado4, Ali Rajabpour-Sanati2,#br# Mohammad Reza Khazdair1, Saeed Samarghandian5, 6#br#   

  1. 1 Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
    2 Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
    3 Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran
    4 Department of Medical Sciences, Faculty of Medicine of Albacete, Centro Regional de Investigaciones Biomédicas (CRIB), University of Castilla-La Mancha, Albacete, Spain
    5 Healthy Ageing Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran
    6 Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran
  • Online:2020-10-15 Published:2020-08-04
  • Contact: Saeed Samarghandian,samarghandians1@nums.ac.ir.

摘要:

orcid: 0000-0001-5461-9579 (Saeed Samarghandian)

Abstract: The over-activated microglial cells induce neuroinflammation which has the main role in neurological disorders. The over-activated microglia can disturb neuronal function by releasing inflammatory mediators leading to neuronal dysfunctions and death. Thus, inhibition of over-activated microglia may be an effective therapeutic approach for modulating neuroinflammation. Experimental studies have indicated anti- neuroinflammatory effects of flavonoids such as green tea catechins. The current research was aimed to review the effect of green tea catechins in inhibiting microglial cells, inflammatory cascades, and subsequent neurological diseases.

Key words: catechins, green tea, microglia, neuroinflammation, neurological disease