中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (10): 1852-1853.doi: 10.4103/1673-5374.280313

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

胰高血糖素样肽-1:实现神经保护的时候到了

  

  • 出版日期:2020-10-15 发布日期:2020-08-18

Can glucagon-like peptide-1 (GLP-1) analogues make neuroprotection a reality?

Maryna V. Basalay, Sean M. Davidson, Derek M. Yellon    

  1. The Hatter Cardiovascular Institute, University College London, London, UK
  • Online:2020-10-15 Published:2020-08-18
  • Contact: Derek M. Yellon, d.yellon@ucl.ac.uk.

摘要: orcid: 0000-0001-7791-9320 (Derek M. Yellon)

Abstract: Currently, ischemic stroke remains one of the most costly and devas- tating clinical syndromes, accounting for 9% of all deaths and being the second leading cause of death in the world (Davidson et al., 2018). Approximately 20% of strokes are caused by intracerebral hemorrhage, while the other ~80% are classified as ischemic. With the discovery of thrombolysis, reperfusion therapy became an option for the treatment of ischemic stroke. More recently, endovascular recanalization with mechanical thrombectomy has brought about a paradigm shift in the optimal management of patients with large vessel occlusion. Important- ly, early reperfusion is the only therapy that is proven to limit infarct size in patients with acute ischemic stroke. However, despite a success- ful recanalization being achieved in more than 70% of patients treated with mechanical thrombectomy +/– intravenous tissue recombinant plasminogen activator, functional independence (modified Rankin score 0–2 at 3 months after ischemic stroke) is obtained only in ~45% of cases. This reveals the further need to develop new adjunctive neuro- protective treatment strategies alongside reperfusion therapy.