中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (10): 1846-1847.doi: 10.4103/1673-5374.280314

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

孕酮治疗中枢神经系统疾病:多信号通路的单个分子

  

  • 出版日期:2020-10-15 发布日期:2020-08-06

Progesterone for the treatment of central nervous system disorders: the many signaling roads for a single molecule

Susana Laura González   

  1. Universidad de Buenos Aires, Facultad de Medicina, Departamento de Bioquímica Humana, Buenos Aires; Laboratorio de Nocicepción y Dolor Neuropático, Instituto de Biología y Medicina Experimental, CONICET, Buenos Aires, Argentina
  • Online:2020-10-15 Published:2020-08-06
  • Contact: Susana Laura González, PhD,sgonzalez@dna.uba.ar.
  • Supported by:
    This work was partly supported by grants from Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET, PIP 112-201501-00266), Agencia Nacional de Promoción Científica y Técnica (PICT 2018-02152), Fundación René Barón and Fundación Williams.

摘要: orcid: 0000-0002-1867-042X (Susana Laura González)

Abstract: Central nervous system (CNS) injuries and neurodegenerative diseases show a broad spectrum of common pathophysiological processes, including oxidative stress, neuroinflammation, excitotoxicity, demyelination and neurotransmission dysfunctions. Over the past decades, valuable experimental investigations have helped to clarify the role and timing of these multiple molecular and cellular mechanisms in each of these particular disorders, which usually overlap and critically contribute to long-term disability. However, up to now, no definite cures or effective disease-modifying therapies are available for any of these conditions. This has led to an active search of novel therapeutic approaches, including the repositioning of existing drugs for new indications, as a valid approach to promptly move candidate molecules to clinical trials.