中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (10): 1854-1855.doi: 10.4103/1673-5374.280316

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当左侧知道右侧发生了什么事时–对侧神经元和远端神经元的损伤

  

  • 出版日期:2020-10-15 发布日期:2020-08-19

When the left side knows something happened to the right – sensing injury in neurons contralateral and remote to injury

Valerie M.K. Verge1, Jovan C.D. Hasmatali1,2,3, Vikram Misra3   

  1. 1 Department of Anatomy, Physiology and Pharmacology, Cameco MS Neuroscience Research Center, University of Saskatchewan, Saskatoon, Saskatchewan, Canada 2 Department of Critical Care Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada  3 Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
  • Online:2020-10-15 Published:2020-08-19
  • Contact: Valerie M.K. Verge, PhD, valerie.verge@usask.ca.
  • Supported by:
    This work was supported by Canadian Institutes of Health Research (CIHR) grants No. 74747 and 14238 to VMKV and by a Natural Sciences and Science and Engineering Research Council (NSERC) of Canada grant to VM. JCDH was supported by University of Saskatchewan College of Graduate and Postdoctoral Studies Scholarships.

摘要: orcid: 0000-0001-6648-3242 (Valerie M.K. Verge)

Abstract: How sensory neurons encode axonal injury signals has been a longstanding area of neurological research. Insights into the cellular and transcriptional changes in the injured neurons have driven many new therapeutic strategies to improve repair. In contrast, less focus has been centered on the systemic or transneuronal changes that may arise from these injuries and how they may impact or factor into the alterations in gene expression, physiology and neuropathology, such as mirror image pain, arising in regions either directly contralateral or those remote to the injury site. Research in this area is clinically relevant. In patients with chronic unilateral pain due to multiple pathologies, many of which involve nerve trauma, there is a very high incidence of bilateral sensory abnormalities reported with 33–50% of patients with mechanical abnormalities reporting contralateral sensory abnormalities (Konopka et al., 2012). This has implications when evaluating sensory abnormalities or pain states in patients, as the contralateral side is often used as the non-affected control. Further, the bilateral nature of these sensory abnormalities, albeit usually less severe on the contralateral side, support that a systemic or central nervous system component is involved in this aspect of the pathology. It highlights the need to better understand the mechanisms underlying these bilateral responses as this will likely impact therapeutic treatments for these patients.