中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (12): 2173-2185.doi: 10.4103/1673-5374.284976

• 综述:退行性病与再生 •    下一篇

多巴胺:一种免疫递质

  

  • 出版日期:2020-12-15 发布日期:2020-08-04

Dopamine: an immune transmitter

Sarah Thomas Broome1, Krystal Louangaphay1, Kevin A. Keay2, Gian Marco Leggio3, Giuseppe Musumeci4, Alessandro Castorina1, 2   

  1. 1 Laboratory of Cellular and Molecular Neuroscience (LCMN), School of Life Science, Faculty of Science, University of Technology Sydney, Sydney, Australia
    2 Laboratory of Neural Structure and Function (LNSF), School of Medical Sciences, (Anatomy and Histology), Faculty of Medicine and Health, University of Sydney, Sydney, Australia
    3 Section of Pharmacology, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
    4 Section of Human Anatomy and Histology, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
  • Online:2020-12-15 Published:2020-08-04
  • Contact: Alessandro Castorina, PhD,alessandro.castorina@uts.edu.au or a.castorina@sydney.edu.au.
  • Supported by:
    This work was partially supported by a Research Development Fund (UTS Start-Up Grant 2018) from the University of Technology Sydney to AC.

摘要: orcid: 0000-0001-7037-759X (Alessandro Castorina)

Abstract: The dopaminergic system controls several vital central nervous system functions, including the control of movement, reward behaviors and cognition. Alterations of dopaminergic signaling are involved in the pathogenesis of neurodegenerative and psychiatric disorders, in particular Parkinson’s disease, which are associated with a subtle and chronic inflammatory response. A substantial body of evidence has demonstrated the non-neuronal expression of dopamine, its receptors and of the machinery that governs synthesis, secretion and storage of dopamine across several immune cell types. This review aims to summarize current knowledge on the role and expression of dopamine in immune cells. One of the goals is to decipher the complex mechanisms through which these cell types respond to dopamine, in order to address the impact this has on neurodegenerative and psychiatric pathologies such as Parkinson’s disease. A further aim is to illustrate the gaps in our understanding of the physiological roles of dopamine to encourage more targeted research focused on understanding the consequences of aberrant dopamine production on immune regulation. These highlights may prompt scientists in the field to consider alternative functions of this important neurotransmitter when targeting neuroinflammatory/neurodegenerative pathologies.

Key words: astrocyte, autoimmune disease, dopamine, dopamine receptors, D3R, immune transmitter, microglia, multiple sclerosis, neuroinflammation, Parkinson’s disease