中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (12): 2207-2216.doi: 10.4103/1673-5374.284978

• 综述:视神经损伤修复保护与再生 • 上一篇    下一篇

药用植物和天然产物作为年龄相关性黄斑变性的神经保护剂

  

  • 出版日期:2020-12-15 发布日期:2020-08-04

Medicinal plants and natural products as neuroprotective agents in age-related macular degeneration

Francisco Bosch-Morell1, 2, Victoria Villagrasa3, Teresa Ortega4, Nuria Acero5, Dolores Muñoz-Mingarro6, M. Eugenia González-Rosende3, Encarna Castillo3, M. Amparo Sanahuja3, Pilar Soriano7, Isabel Martínez-Solís1, 3, 7#br#   

  1. 1 Biomedical Sciences Institute, Universidad Cardenal Herrera-CEU, CEU Universities, Alfara del Patriarca, Valencia, Spain
    2 Department of Biomedical Sciences, Faculty of Health Sciences, Universidad Cardenal Herrera-CEU, CEU Universities, Alfara del Patriarca, Valencia, Spain
    3 Department of Pharmacy, Faculty of Health Sciences, Universidad Cardenal Herrera-CEU, CEU Universities, Alfara del Patriarca, Valencia, Spain
    4 Department of Pharmacology, Pharmacognosy and Botany, Universidad Complutense de Madrid, Madrid, Spain
    5 Department of Pharmaceutical and Health Sciences, Faculty of Pharmacy, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain
    6 Department of Chemistry and Biochemistry, Faculty of Pharmacy, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain
    7 ICBiBE-Botanical Garden, University of Valencia, Valencia, Spain
  • Online:2020-12-15 Published:2020-08-04
  • Contact: Isabel Martínez-Solís, PhD,isolis@uchceu.es.

摘要: orcid: 0000-0001-8913-6198 (Isabel Martínez-Solís)

Abstract: The retina may suffer neurodegenerative damages, as other tissues of the central nervous system do, and serious eye diseases may develop. One of them is age-related macular degeneration, which causes progressive loss of vision due to retina degeneration. Treatment of age-related macular degeneration focuses on antioxidant agents and anti-vascular endothelial growth factor compounds, among others, that prevent/ diminish oxidative stress and reduce neovascularisation respectively. The phytochemicals, medicinal plants and/or plant-diet supplements might be a useful adjunct in prevention or treatment of age-related macular degeneration owing to their antioxidant and anti-vascular endothelial growth factor properties. This review article presents the most investigated plants and natural products in relation to age-related macular degeneration, such as saffron, ginkgo, bilberry and blueberry, curcuma or turmeric, carotenoids, polyphenols, and vitamins C and E. This study provides up-to-date information on the effects, treatments, safety and efficiency of these phytotherapy products.

Key words: age-related macular degeneration, bilberry, blueberry, curcuma, carotenoids, ginkgo, polyphenols, saffron, vitamins