中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (12): 2241-2242.doi: 10.4103/1673-5374.284985

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

神经营养素3介导的运动恢复:一种针对脊髓损伤后腰神经环路的新型治疗策略

  

  • 出版日期:2020-12-15 发布日期:2020-08-04

Neurotrophin-3-mediated locomotor recovery: a novel therapeutic strategy targeting lumbar neural circuitry after spinal cord injury

Qi Han, Xiao-Ming Xu   

  1. Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute; Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
  • Online:2020-12-15 Published:2020-08-04
  • Contact: Xiao-Ming Xu, MD, PhD, xu26@iupui.edu.
  • Supported by:
    This work was supported in part by NIH 1R01 100531, 1R01 NS103481, Merit Review Award I01 BX002356, I01 BX003705, I01 RX002687 from the USA Department of Veterans Affairs, Mari Hulman George Endowment Funds (to XMX).

摘要: orcid: 0000-0002-7229-0081 (Xiao-Ming Xu)

Abstract: Traumatic spinal cord injury (SCI) leads to chronic locomotor impairment and disability. Unfortunately, there are no effective treatments currently available for SCI patients (Bradbury and Burnside, 2019). Developing novel repair interventions to mitigate the devastating nature of SCI and translating them clinically are urgent medical needs to improve the quality of life of patients with SCI. The lumbar spinal motoneurons (MNs) are the final common pathway for hindlimb locomotion since all neural activities that influence hindlimb movement converging upon these neurons. With above-level (cervical and thoracic) SCIs, the lumbar MNs are not directly injured by the initial mechanical impact, but they undergo profound degeneration with dendritic atrophy and synaptic stripping due to a trauma-induced decrease of supraspinal and propriospinal innervations, leading to impaired locomotor function (Figure 1A; Wang et al., 2018). While most SCI studies have been focused on the neuroregeneration or neuroprotection of injured spinal cord at the lesion site, few studies have explored the potential benefit of modulating lumbar motor circuitry for locomotor recovery after an above-level SCI. Filling this gap is an important task for developing the care and treatment of SCI.