中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (12): 2249-2250.doi: 10.4103/1673-5374.284987

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

远程缺血调节:大脑对卒中的内源性防御

  

  • 出版日期:2020-12-15 发布日期:2020-08-04

Remote ischemic conditioning: the brain’s endogenous defense against stroke

Caleb J. Heiberger, Tej Mehta, Jae Kim, Divyajot S. Sandhu   

  1. University of South Dakota, Sanford School of Medicine, Sioux Falls, SD, USA
  • Online:2020-12-15 Published:2020-08-04
  • Contact: Caleb J. Heiberger, MD, Heiberger.caleb@gmail.com.

摘要: orcid: 0000-0001-5053-1828 (Caleb J. Heiberger) 

Abstract: In 1986, Murray built upon a se- ries of accumulated works to demonstrated that brief ischemic “training” episodes fortified cardiac tissue against impending prolonged infarction (Murry et al., 1986). This discovery altered the dogmatic understanding of ischemia, highlighting that time-dependent tissue compromise during infarction was bimodal, not linear, in nature. Instead of being invariably deleterious, an organ’s response to ischemia is dependent upon both the duration of the infarction as well as adaptions from previous, transient isch- emic episodes.