中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (12): 2258-2259.doi: 10.4103/1673-5374.284991

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

β2肾上腺素能受体激活促进成人海马神经发生

  

  • 出版日期:2020-12-15 发布日期:2020-08-04

Activation of β2 adrenergic receptors promotes adult hippocampal neurogenesis

Valeria Bortolotto, Mariagrazia Grilli    

  1. Laboratory of Neuroplasticity, Department of Pharmaceutical Sciences, University of Piemonte Orientale, Novara, Italy
  • Online:2020-12-15 Published:2020-08-04
  • Contact: Mariagrazia Grilli, MD, PhD, mariagrazia.grilli@uniupo.it.
  • Supported by:
    Tis work was partially supported by Progetti di Rilevante Inter- esse Nazionale (PRIN) 2017.

摘要: orcid: 0000-0001-9165-5827 (Mariagrazia Grilli)

Abstract: Te subgranular zone (SGZ) of the hippocampal dentate gyrus is one of the few central nervous system regions where genera- tion of adult born neurons occurs physiologically. Tis process, referred to as adult hippocampal neurogenesis (ahN), relies on the presence of neural progenitor cells (NPC) in the SGZ neu- rogenic niche. NPC, in response to appropriate cues and sig- nals, give rise to neuroblasts migrating to the granular cell layer (GCL) where they mature into neurons functionally integrated into the hippocampal circuit (Toda et al., 2019). Although the functional role of adult born hippocampal neurons is not fully understood, a vast array of experimental evidence suggest that these cells are involved in crucial hippocampal-dependent func- tions like specifc types of learning and memory and emotional responses (Toda et al., 2019). Intriguingly, deregulated ahN has been associated with several neurodegenerative and neuropsy- chiatric diseases. Major depression, in particular, is one of the disorders where dysregulated ahN has been more extensively studied