中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (1): 93-98.doi: 10.4103/1673-5374.286956

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

周围神经损伤与修复中许旺细胞和其他细胞的相互作用

  

  • 出版日期:2021-01-15 发布日期:2020-11-23

Interaction between Schwann cells and other cells during repair of peripheral nerve injury

Wen-Rui Qu1, Zhe Zhu1, Jun Liu1, De-Biao Song2, Heng Tian1, *, Bing-Peng Chen3, *, Rui Li1, *, Ling-Xiao Deng4   

  1. 1 Department of Hand Surgery, the Second Hospital of Jilin University, Changchun, Jilin Province, China; 2 Department of Emergency and Critical Medicine, the Second Hospital of Jilin University, Changchun, Jilin Province, China;  3 Orthopedic Medical Center, the Second Hospital of Jilin University, Changchun, Jilin Province, China;   4 Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
  • Online:2021-01-15 Published:2020-11-23
  • Contact: Heng Tian, MD, rzlmengtong@163.com; Bing-Peng Chen, MD, PhD, chenbingpeng@jlu.edu.cn; Rui Li, MD, PhD, l_rui@jlu.edu.cn.
  • Supported by:
    This work was also supported by the National Natural Science Foundation of China, No. 81901365; Jilin Science and Technology Agency Funds in China, Nos. 20180101118JC, 20180520115JH and 20190103076JH.

摘要:

https://orcid.org/0000-0001-7354-1375 (Heng Tian); 

https://orcid.org/0000-0001-7043-0848 (Bing-Peng Chen); 

https://orcid.org/0000-0001-7857-9735 (Rui Li)

Abstract: Peripheral nerve injury (PNI) is common and, unlike damage to the central nervous system injured nerves can effectively regenerate depending on the location and severity of injury. Peripheral myelinating glia, Schwann cells (SCs), interact with various cells in and around the injury site and are important for debris elimination, repair, and nerve regeneration. Following PNI, Wallerian degeneration of the distal stump is rapidly initiated by degeneration of damaged axons followed by morphologic changes in SCs and the recruitment of circulating macrophages. Interaction with fibroblasts from the injured nerve microenvironment also plays a role in nerve repair. The replication and migration of injury-induced dedifferentiated SCs are also important in repairing the nerve. In particular, SC migration stimulates axonal regeneration and subsequent myelination of regenerated nerve fibers. This mobility increases SC interactions with other cells in the nerve and the exogenous environment, which influence SC behavior post-injury. Following PNI, SCs directly and indirectly interact with other SCs, fibroblasts, and macrophages. In addition, the inter- and intracellular mechanisms that underlie morphological and functional changes in SCs following PNI still require further research to explain known phenomena and less understood cell-specific roles in the repair of the injured peripheral nerve. This review provides a basic assessment of SC function post-PNI, as well as a more comprehensive evaluation of the literature concerning the SC interactions with macrophages and fibroblasts that can influence SC behavior and, ultimately, repair of the injured nerve.

Key words: axon regeneration, cell-cell interactions, nerve injury, nerve repair, peripheral nerve, recovery, regeneration, repair, Schwann cell migration