中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (1): 80-92.doi: 10.4103/1673-5374.286955

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

脑卒中损伤后神经再生和功能恢复:神经干细胞治疗正朝着临床应用迈进

  

  • 出版日期:2021-01-15 发布日期:2020-11-23

Neuroregeneration and functional recovery after stroke: advancing neural stem cell therapy toward clinical application

Yang Jiao1, 2, Yu-Wan Liu1, Wei-Gong Chen1, 2, Jing Liu1, 2, *   

  1. 1 Stem Cell Clinical Research Center, National Joint Engineering Laboratory, Regenerative Medicine Center, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China;  2 Dalian Innovation Institute of Stem Cells and Precision Medicine, Dalian, Liaoning Province, China 
  • Online:2021-01-15 Published:2020-11-23
  • Contact: Jing Liu, PhD, liujing@dmu.edu.cn.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, No. 81471308; Program of China National Health Commission and National Medical Products Administration (NMPA), No. CMR-20161129-1003; Liaoning Province Excellent Talent Program Project, No. XLYC1902031; Dalian Innovation Fund, No. 2018J11CY025.

摘要:

https://orcid.org/0000-0002-0493-296X (Jing Liu);

https://orcid.org/0000-0001-8476-7978 (Yang Jiao) 

Abstract: Stroke is a main cause of death and disability worldwide. The ability of the brain to self-repair in the acute and chronic phases after stroke is minimal; however, promising stem cell-based interventions are emerging that may give substantial and possibly complete recovery of brain function after stroke. Many animal models and clinical trials have demonstrated that neural stem cells (NSCs) in the central nervous system can orchestrate neurological repair through nerve regeneration, neuron polarization, axon pruning, neurite outgrowth, repair of myelin, and remodeling of the microenvironment and brain networks. Compared with other types of stem cells, NSCs have unique advantages in cell replacement, paracrine action, inflammatory regulation and neuroprotection. Our review summarizes NSC origins, characteristics, therapeutic mechanisms and repair processes, then highlights current research findings and clinical evidence for NSC therapy. These results may be helpful to inform the direction of future stroke research and to guide clinical decision-making. 

Key words: brain, central nervous system, cognitive impairment, neurological function, plasticity, recovery, regeneration, stem cells, stroke