中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (4): 690-691.doi: 10.4103/1673-5374.289435

• 观点:视神经损伤修复保护与再生 • 上一篇    下一篇

角膜共聚焦显微镜图像分析角膜神经丛

  

  • 出版日期:2021-04-15 发布日期:2020-12-21

Analysis of corneal nerve plexus in corneal confocal microscopy images

Yu-Chi Liu*, Molly Tzu-Yu Lin, Jodhbir S. Mehta   

  1. Tissue Engineering and Cell Therapy Group, Singapore Eye Research Institute, Singapore 
    (Liu YC, Lin MTY, Mehta JS)
    Department of Cornea and External Eye Disease, Singapore National Eye Centre; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore (Liu YC, Mehta JS)
  • Online:2021-04-15 Published:2020-12-21
  • Contact: Yu-Chi Liu, MD, liuchiy@gmail.com.
  • Supported by:

    如果您需要向SCI收录期刊投稿,我们可以为您提供如下服务-- 

    稿件查重;
    翻译润色;
    投稿咨询包括编辑投稿信,选审稿人,文章调整格式,在线投稿等问题的解决等;
    免费为作者申请学术身份识别码(ORCID);
    免费为专家申请成为国际审稿人(Publons);
    代投“读者来信”类文章:可将审稿人对SCI杂志出版后文章的评价或讨论向被评价期刊投稿;
    临床试验方案注册;
    论文基础数据注册;
    免费推荐投稿期刊和论文评估;
    去国际优秀实验室或优秀临床科室长期或短期学习进修;
    与国际优秀实验室或优秀临床科室、优秀期刊联系听高端讲座开展基础或临床项目合作。

摘要: https://orcid.org/0000-0001-5408-0382 (Yu-Chi Liu) 

Abstract: Small Aδ and C nerve fibers of the sensory and autonomic nervous systems constitute 70–90% of peripheral nerve fibers including corneal nerves (Muller et al., 2003). Corneal nerves originate from the ophthalmic branch of the trigeminal nerve and enter the cornea at the limbus radially from all directions toward the central cornea at the level of anterior and middle stroma. The subepithelial nerve plexus lies at the interface between the Bowman layer and anterior stroma. They then divide into smaller branches and turn 90° toward Bowman’s layer (Muller et al., 2003), travelling between Bowman’s layer and the basal epithelial layer and forming the sub-basal nerve plexus (Muller et al., 2003). Innervation of the cornea is comprised almost entirely of unmyelinated type C nerve fibers, with the fiber width ranging between 0.2–2.0 μm. Corneal nerves not only provide important sensory function but also maintain the functional integrity of the ocular surface by releasing trophic substances that promote corneal epithelial homeostasis and by activating brainstem circuits that stimulate reflex tear production and blinking (Marfurt et al., 2010). Disruption of corneal nerves result in reduced or absent corneal sensations as well as negative impacts on the ocular surface integrity and tear film dynamics, leading to dry eye symptoms, corneal epithelial breakdown, and neurotrophic keratopathy (Al-Aqaba et al., 2019).