中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (2): 234-241.doi: 10.4103/1673-5374.290879

• 综述:退行性病与再生 • 上一篇    下一篇

多酚对帕金森病的潜在治疗作用:体内和体外临床前研究

  

  • 出版日期:2021-02-15 发布日期:2020-12-01

Potential therapeutic effects of polyphenols in Parkinson’s disease: in vivo and in vitro pre-clinical studies

Claudio Giuliano, Silvia Cerri, Fabio Blandini*   

  1. Laboratory of Cellular and Molecular Neurobiology, IRCCS Mondino Foundation, Pavia, Italy
  • Online:2021-02-15 Published:2020-12-01
  • Contact: Fabio Blandini, MD, fabio.blandini@mondino.it.

摘要: https://orcid.org/0000-0002-0178-1289 (Fabio Blandini)

Abstract: Parkinson’s disease is a neurodegenerative disorder characterized by a combination of severe motor and non-motor symptoms. Over the years, several factors have been discovered to play a role in the pathogenesis of this disease, in particular, neuroinflammation and oxidative stress. To date, the pharmacological treatments used in Parkinson’s disease are exclusively symptomatic. For this reason, in recent years, the research has been directed towards the discovery and study of new natural molecules to develop potential neuroprotective therapies against Parkinson’s disease. In this context, natural polyphenols have raised much attention for their important anti-inflammatory and antioxidant properties, but also for their ability to modulate protein misfolding. In this review, we propose to summarize the relevant in vivo and in vitro studies concerning the potential therapeutic role of natural polyphenols in Parkinson’s disease.

Key words: alpha-synuclein, anti-in?ammatory, antioxidants, natural molecules, neuroprotection, Parkinson’s disease, polyphenols, syntomatic effect