中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (2): 289-290.doi: 10.4103/1673-5374.290887

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

涉及少突胶质细胞分化的新型半乳凝素3相互作用进入脱髓鞘疾病的治疗策略

  

  • 出版日期:2021-02-15 发布日期:2020-12-02

Novel Galectin-3 interactions involved in oligodendroglial differentiation make inroads into therapeutic strategies for demyelinating diseases

Laura Andrea Pasquini*   

  1. Department of Biological Chemistry, School of Pharmacy and Biochemistry, Institute of Biological Chemistry and Physicochemistry (IQUIFIB), University of Buenos Aires and National Research Council (CONICET), Buenos Aires, Argentina
  • Online:2021-02-15 Published:2020-12-02
  • Contact: Laura Andrea Pasquini, PhD,laupasq@yahoo.com.
  • Supported by:
    This work was supported by grants from Agencia Nacional de Promoción Científica y Tecnológica (Argentina, PICT 2016-0319) and Universidad de Buenos Aires (20920160100683BA, to LAP).

摘要: https://orcid.org/0000-0003-4292-3463(Laura Andrea Pasquini)

Abstract: Galectins (Gals) constitute a 15-member class of β-galactoside-binding lectins which recognize N-acetyllactosamine. Despite lacking specific receptors, Gals form multivalent complexes with cell surface glycoconjugates containing suitable oligosaccharides and thus trigger intracellular signals to regulate cell survival and differentiation. Gals are classified into three groups on the basis of their structural architecture: proto, chimera and tandem types, with Gal-3 being the only representative of the chimeric type. Regarding intracellular localization, Gal-3 is found in both cell cytoplasm and nucleus. Extracellular Gal-3 can also be endocyted and, together with intracellular Gal-3, modulate diverse functions binding to intracellular molecules. While lacking a secretion signal peptide, Gal-3 is still secreted into the extracellular space by non-classical pathways potentially involving exosomes. Once secreted, Gal-3 binds to poly-N-acetyllactosamine in the extracellular matrix and membrane receptors, laying bridges to promote or inhibit intracellular events (Thomas and Pasquini, 2018).