中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (2): 304-305.doi: 10.4103/1673-5374.290894

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

醉茄素A在神经系统疾病中的治疗意义

  

  • 出版日期:2021-02-15 发布日期:2020-12-03

Implications of Withaferin A in neurological disorders

Natasha Ram, Stephanie L. Peak, Andres R. Perez, Umesh K. Jinwal*   

  1. Department of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL, USA
  • Online:2021-02-15 Published:2020-12-03
  • Contact: Umesh K. Jinwal, PhD, jinwalu@usf.edu.
  • Supported by:
    The authors thank Taneja College of Pharmacy, College of Arts and Sciences, and Office of Undergraduate Research, USF for providing supports.

摘要: https://orcid.org/0000-0001-5279-527X(Umesh K. Jinwal)

Abstract: Extract from the medicinal herb Withania somnifera (WS), commonly known as Ashwagandha, has therapeutic implications in various conditions such as infection, inflammation, cancer, stress, neurodegenerative diseases, heart disease, diabetes, and others. Withaferin A (WA), a relatively nontoxic steroidal lactone isolated from WS extract, has often been tested for its anti-tumor properties (Dar et al., 2015; Marlow et al., 2017). It has been demonstrated that WA may also serve as a neuroprotectant in a number of neurological conditions, including Parkinson’s disease (PD), cerebral infarctions (CI), reactive gliosis, amyotrophic lateral sclerosis (ALS), and human immunodeficiency virus-associated neurological dysfunctions (HIV-AND).