中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (4): 643-652.doi: 10.4103/1673-5374.295273

• 综述:退行性病与再生 • 上一篇    下一篇

Hippo信号通路:架起癌症和神经退行性疾病的桥梁

  

  • 出版日期:2021-04-15 发布日期:2020-12-21

Hippo signaling: bridging the gap between cancer and neurodegenerative disorders

Neha Gogia1, #, Anuradha Venkatakrishnan Chimata1, #, Prajakta Deshpande1, #,Aditi Singh2, Amit Singh1, 3, 4, 5, 6, *   

  1. 1 Department of Biology, University of Dayton, Dayton, OH, USA;  2 Medical Candidate, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA;  3 Premedical Program, University of Dayton, Dayton, OH, USA;  4 Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, OH, USA;  5 The Integrative Science and Engineering Center, University of Dayton, Dayton, OH, USA;  6 Center for Genomic Advocacy (TCGA), Indiana State University, Terre Haute, IN, USA
  • Online:2021-04-15 Published:2020-12-21
  • Contact: Amit Singh, PhD, asingh1@udayton.edu.
  • Supported by:
    The authors are supported by the University of Dayton Graduate program of Biology. This work was supported by NIH1R15GM124654-01 from the National Institutes of Health, Schuellein Chair Endowment Fund, and start-up support from the University of Dayton (to Amit S). 

摘要: https://orcid.org/0000-0002-2962-2255 (Amit Singh) 

Abstract: During development, regulation of organ size requires a balance between cell proliferation, growth and cell death. Dysregulation of these fundamental processes can cause a variety of diseases. Excessive cell proliferation results in cancer whereas excessive cell death results in neurodegenerative disorders. Many signaling pathways known-to-date have a role in growth regulation. Among them, evolutionarily conserved Hippo signaling pathway is unique as it controls both cell proliferation and cell death by a variety of mechanisms during organ sculpture and development. Neurodegeneration, a complex process of progressive death of neuronal population, results in fatal disorders with no available cure to date.  During normal development, cell death is required for sculpting of an organ. However, aberrant cell death in neuronal cell population can result in neurodegenerative disorders. Hippo pathway has gathered major attention for its role in growth regulation and cancer, however, other functions like its role in neurodegeneration are also emerging rapidly. This review highlights the role of Hippo signaling in cell death and neurodegenerative diseases and provide the information on the chemical inhibitors employed to block Hippo pathway. Understanding Hippo mediated cell death mechanisms will aid in development of reliable and effective therapeutic strategies in future. 

Key words: animal models, cell death mechanisms, cell-signaling, chemical inhibitors, Drosophila eye, Hippo pathway, neurodegeneration, neurological diseases, therapeutic targets