中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (4): 618-620.doi: 10.4103/1673-5374.295312

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

埃博霉素在中枢神经系统创伤治疗中的功效:与年龄有关?

  

  • 出版日期:2021-04-15 发布日期:2020-12-21

Efficacy of epothilones in central nervous system trauma treatment: what has age got to do with it?

Jayden Clark#, Zhendan Zhu#, Jyoti Chuckowree, Tracey Dickson, Catherine Blizzard*#br#   

  1. Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
  • Online:2021-04-15 Published:2020-12-21
  • Contact: Catherine Blizzard, PhD, Catherine.Blizzard@utas.edu.au.

摘要: https://orcid.org/0000-0002-8683-2937 (Catherine Blizzard) 

Abstract: Central nervous system injury, specifically traumatic brain and spinal cord injury, can have significant long lasting effects. There are no comprehensive treatments to combat the injury and sequalae of events that occurring following a central nervous system trauma. Herein we discuss the potential for the epothilone family of microtubule stabilizing agents to improve outcomes following experimentally induced trauma. These drugs, which are able to cross the blood-brain barrier, may hold great promise for the treatment of central nervous system trauma and the current literature presents the extensive range of beneficial effects these drugs may have following trauma in animal models. Importantly, the effect of the epothilones can vary and our most recent contributions to this field indicate that the efficacy of epothilones following traumatic brain injury is dependent upon the age of the animals. Therefore, we present a case for a greater emphasis to be placed upon age when using an intervention aimed at neural regeneration and highlight the importance of tailoring the therapeutic regime in the clinic to the age of the patient to promote improved patient outcomes.

Key words: aging, epothilones, glial, microtubule stablization, neuron, neuronal regeneration, spinal cord injury, traumatic brain injury