中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (4): 676-677.doi: 10.4103/1673-5374.295327

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

发育中枢神经系统中的Sox9 –万事通?

  

  • 出版日期:2021-04-15 发布日期:2020-12-21

Sox9 in the developing central nervous system: a jack of all trades?

Julia K. Vogel, Michael Wegner*   

  1. Institut für Biochemie, Emil-Fischer-Zentrum, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
  • Online:2021-04-15 Published:2020-12-21
  • Contact: Michael Wegner, PhD,michael.wegner@fau.de.
  • Supported by:
    This work was supported by grants from the Deutsche Forschungsgemeinschaft, No. We1326/14 and We1326/15 to MW.

摘要: https://orcid.org/0000-0002-4586-3294 (Michael Wegner);
https://orcid.org/0000-0002-9890-5670 (Julia K. Vogel)

Abstract: Neurons and glial cells are the major neuroectodermal cell types of the vertebrate central nervous system (CNS). Their generation from common progenitor cells takes place mostly during embryonic and early postnatal development. After closure of the neural tube, neural epithelial progenitor cells (NEPs) establish the ventricular zone (VZ). By asymmetrical cell division, NEPs first give rise to neuronal precursor cells (NPs) that then differentiate into various types of neurons. Later, NEPs predominantly produce glial precursor cells that become either astroglia or oligodendroglia.