中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (5): 982-983.doi: 10.4103/1673-5374.297071

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

周细胞的多重角色

  

  • 出版日期:2021-05-15 发布日期:2020-12-29

Multifaceted roles of pericytes-interorgan interactions

Zhitong Zheng, Michael Chopp*, Jieli Chen*   

  1. Department of Neurology, Henry Ford Hospital, Detroit, MI, USA (Zheng Z, Chopp M, Chen J)
    Department of Physics, Oakland University, Rochester, MI, USA (Chopp M)
  • Online:2021-05-15 Published:2020-12-29
  • Contact: Jieli Chen, MD, jchen4@hfhs.org; Michael Chopp, PhD, mchopp1@hfhs.org.
  • Supported by:
    This work was supported by the National Heart, Lung, and Blood Institute R01HL143432 (to JC).

摘要: https://orcid.org/0000-0001-5446-9101(Jieli Chen) 

Abstract: Microvascular dysfunction has been implicated in many diseases such as stroke and diabetes. In addition to the microvascular endothelial cell (EC), the pericyte, a perivascular cell that adheres to the abluminal side of the EC may also be important to ensure proper microvascular function. As a prominent perivascular cell, the pericyte has garnered increasing attention for its multiple functional aspects, especially the pericyte of central nervous system (Yemisci et al., 2009; Armulik et al., 2010; Gaceb et al., 2018). The integrity of the blood-brain barrier (BBB), regulation of cerebral blood flow, and proper functioning of the glymphatic and immune defense systems may all be dependent on the coordination between brain pericytes and their neighboring cells (Yemisci et al., 2009; Armulik et al., 2010; Gaceb et al., 2018). Since the brain communicates with all peripheral organs, pericyte dysfunction in brain and in peripheral organs may, respectively, adversely impact peripheral organs and brain. Thus, pericyte behavior may provide potential links in the communication axis of brain and peripheral organs. In this perspective, we discuss associations of pericyte functions and pathologies between brain and selective peripheral organs, and elucidation of which may lead to novel therapeutic applications.