中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (6): 1223-1224.doi: 10.4103/1673-5374.300446

• 观点:周围神经损伤修复保护与再生 • 上一篇    

外周神经中的凝血酶:是敌还是友?

  

  • 出版日期:2021-06-15 发布日期:2020-12-31

Thrombin in peripheral nerves: friend or foe?

Elena Pompili*, Cinzia Fabrizi   

  1. Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University, Rome, Italy
  • Online:2021-06-15 Published:2020-12-31
  • Contact: Elena Pompili,elena.pompili@uniroma1.it.
  • Supported by:
    This work was supported by grants from 
    Sapienza University to CF (RM118164328DF7F2 and RM11916B88BF39BB).

摘要: https://orcid.org/0000-0002-8349-6982 (Elena Pompili)

Abstract: Differently from the central nervous system (CNS), the peripheral nervous system (PNS) exhibits a high regenerative capacity. This ability is  related to the remarkable plasticity of Schwann cells (SCs) which after nerve injury convert to a repair-promoting phenotype to a large extent. Nerve injury is accompanied by a rapid rise of thrombin levels (Bushi et al., 2016; Gera et al., 2016). Thrombin is the key effector protease of the coagulation cascade which elicits hormone-like actions by the activation of G-protein coupled receptors known as protease-activated receptors (PARs). Inflammation and coagulation are two complex and interconnected pathways whose mutual interactions have been only partially elucidated.