中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (7): 1359-1368.doi: 10.4103/1673-5374.300975

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

脱髓鞘-髓鞘再形成和神经变性过程中的动态神经胶质反应和串扰

  

  • 出版日期:2021-07-15 发布日期:2021-01-07

Dynamic glial response and crosstalk in demyelination-remyelination and neurodegeneration processes

Tianci Chu1, Lisa B.E. Shields2, Wenxin Zeng1, Yi Ping Zhang2, Yuanyi Wang3, Gregory N. Barnes1, 4, 5, Christopher B. Shields2, 6, *, Jun Cai1, 5, *#br#   

  1. 1 Pediatric Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY, USA;  2 Norton Neuroscience Institute, Norton Healthcare, Louisville, KY, USA;  3 Department of Spine Surgery, The First Hospital of Jilin University, Changchun, Jilin Province, China;  4 Department of Neurology, University of Louisville School of Medicine, Louisville, KY, USA;  5 Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA;  6 Department of Neurological Surgery, University of Louisville School of Medicine, Louisville, KY, USA
  • Online:2021-07-15 Published:2021-01-07
  • Contact: Jun Cai, MD, PhD, j0cai002@louisville.edu; Christopher B. Shields, MD, cbshields1@gmail.com.
  • Supported by:
    This work was partially supported by grants from the National Institute of Neurological Disorders and Stroke of the National Institutes of Health (R21 NS098170, to JC and CBS), Kentucky Spinal Cord and Head Injury Research Trust (16-3A, to JC and CBS), and the National Natural Science Foundation of China (81601957, to YW).

摘要:

https://orcid.org/0000-0003-1721-7786 (Jun Cai); 

https://orcid.org/0000-0002-4450-8135 (Christopher B. Shields)

Abstract: Multiple sclerosis is an autoimmune disease in which the immune system attacks the myelin sheath in the central nervous system. It is characterized by blood-brain barrier dysfunction throughout the course of multiple sclerosis, followed by the entry of immune cells and activation of local microglia and astrocytes. Glial cells (microglia, astrocytes, and oligodendrocyte lineage cells) are known as the important mediators of neuroinflammation, all of which play major roles in the pathogenesis of multiple sclerosis. Network communications between glial cells affect the activities of oligodendrocyte lineage cells and influence the demyelination-remyelination process. A finely balanced glial response may create a favorable lesion environment for efficient remyelination and neuroregeneration. This review focuses on glial response and neurodegeneration based on the findings from multiple sclerosis and major rodent demyelination models. In particular, glial interaction and molecular crosstalk are discussed to provide insights into the potential cell- and molecule-specific therapeutic targets to improve remyelination and neuroregeneration. 

Key words: astrocyte, crosstalk, demyelination, glial response, microglia/macrophage, multiple sclerosis, neurodegeneration, neuroinflammation, oligodendrocyte lineage cells, remyelination ,