中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (12): 2353-2358.doi: 10.4103/1673-5374.300981

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

神经球蛋白的神经保护作用：神经球蛋白药理诱导中天然以及合成化合物的作用

  

  • 出版日期:2021-12-15 发布日期:2021-05-13

Neuroglobin and neuroprotection: the role of natural and synthetic compounds in neuroglobin pharmacological induction

Lidia Ciccone1, Susanna Nencetti1, Simone Socci2, Elisabetta Orlandini2, 3, *   

  1. 1Department of Pharmacy, University of Pisa, Pisa, Italy; 2Department of Earth Sciences, University of Pisa, Pisa, Italy; 3Research Center “E. Piaggio,” University of Pisa, Pisa, Italy
  • Online:2021-12-15 Published:2021-05-13
  • Contact: Elisabetta Orlandini, PhD, elisabetta.orlandini@unipi.it.
  • Supported by:
    This work was supported by the Italian Ministero dell’Istruzione, dell’Universitá e della Ricerca PRIN 2017SNRXH3 (to EO and SN); PRA_2018_20 University of Pisa (to EO).

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摘要：

Neural Regen Res：神经球蛋白对退行性疾病的神经保护作用：天然与合成化合物扮演的角色

神经球蛋白（Ngb）属于球蛋白家族的17 kDa单体六配位血红素蛋白，主要在中枢神经系统和周围神经系统的神经元中表达。在过去的十年中，已经对Ngb在多种神经系统疾病（例如阿尔茨海默病、亨廷顿病、脑缺血）中的神经保护作用进行了研究。

来自意大利比萨大学的Elisabetta Orlandini团队最近研究表明Ngb同胱抑素C、载脂蛋白A1和运甲状腺素蛋白一样对阿尔茨海默病具有潜在的保护作用。他们团队还整理并讨论了迄今为止发现的可以当作Ngb药理诱导剂的天然和合成化合物，重点介绍了可以启发未来设计、调节Ngb水平的新分子的化学结构。Ngb过表达诱导的内源性神经保护代表一种成功的治疗策略，并且天然和合成分子对Ngb的药理诱导可能是神经退行性疾病一种潜在治疗方法。

文章在《中国神经再生研究（英文版）》杂志2021年12月12期发表。

https://orcid.org/0000-0003-3398-2787 (Elisabetta Orlandini)

Abstract: Neuroglobin (Ngb) is a 17 kDa monomeric hexa-coordinated heme protein belonging to the globin family. Ngb is mainly expressed in neurons of the central and peripheral nervous system, although moderate levels of Ngb have been detected in non-nervous tissues. In the past decade, Ngb has been studied for its neuroprotective role in a large number of neurological disorders such as Alzheimer’s disease, Huntington’s disease, brain ischemia and hypoxia. This review discusses and summarizes the natural compounds and the small synthetic molecules capable of modulating Ngb expression that exhibits a protective role against various neurodegenerative diseases.

Key words: Neuroglobin, neuroglobin pharmacological induction, neuroprotection, neurodegenerative diseases, natural compounds, synthetic small molecules, Alzheimer’s disease, Huntington’s disease