中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (7): 1421-1422.doi: 10.4103/1673-5374.300994

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

星形胶质细胞源性小泡介导神经血管单元的细胞间通讯

  

  • 出版日期:2021-07-15 发布日期:2021-01-07

Astrocyte-derived extracellular vesicles mediate intercellular communications of the neurogliovascular unit

Augustas Pivoriūnas*, Alexei Verkhratsky   

  1. Department of Stem Cell Biology, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania (Pivoriūnas A, Verkhratsky A)
    Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK (Verkhratsky A)
    Achucarro Centre for Neuroscience, IKERBASQUE, Basque Foundation for Science, Bilbao, Spain (Verkhratsky A)
  • Online:2021-07-15 Published:2021-01-07
  • Contact: Augustas Pivoriūnas, MD, PhD, augustas.pivoriunas@imcentras.lt.
  • Supported by:
    This work was supported by the Global Grant measure (No. 09.3.3-LMTK-712-01-0082; to AP and AV). 

摘要: https://orcid.org/0000-0001-7009-2535 (Augustas Pivoriūnas) 

Abstract: The cortical grey matter of mammals has a specific cyto-architecture defined by the process of “tiling” in which protoplasmic astrocytes parcellate the nervous tissue into spatially segregated territorial domains. Within these domains astrocytes integrate neuronal structures, microglial cells and neighboring capillaries into the neuro-gliovascular unit or neurogliovascular unit (NGVU) (Verkhratsky and Nedergaard, 2018; Sweeney et al., 2019). Signaling within NGVU is of fundamental importance for sustaining brain function, while disruptions of these signaling pathways define many aspects of neuropathology.