中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (7): 1425-1426.doi: 10.4103/1673-5374.301005

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

神经元活动的阶段特定操作:未来的中风疗法

  

  • 出版日期:2021-07-15 发布日期:2021-01-07

Phase-specific manipulation of neuronal activity: a promising stroke therapy approach

Dennis A. Turner*, Wei Yang*   

  1. Departments of Neurosurgery, Neurobiology and Biomedical Engineering, Duke University Medical Center, Durham, NC, USA (Turner DA)
    Research and Surgery Services, Durham VAMC, Durham, NC, USA (Turner DA)
    Center for Perioperative Organ Protection, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA (Yang W)
  • Online:2021-07-15 Published:2021-01-07
  • Contact: Dennis A. Turner, MA, MD, dennis.turner@duke.edu; Wei Yang, PhD,wei.yang@duke.edu.
  • Supported by:
    The present work was supported by NIH NS103468, NS111093, and NS040984-11 (to DAT), and NIH NS099590 and AHA 18CSA34080277 (to WY). 

摘要: https://orcid.org/0000-0001-7118-0764 
(Dennis A. Turner)
https://orcid.org/0000-0001-5719-4393 
(Wei Yang)

Abstract: Introduction: Ischemic stroke accounts for ~87% of all stroke cases (Virani et al., 2020). It is a leading cause of death and long-term disability worldwide, and constitutes a major burden for families and healthcare systems alike. Although medical treatment can help prevent stroke, post-stroke treatment is limited to either pharmacologic (e.g., tissue plasminogen activator - tPA) or mechanical (e.g., thrombectomy) reperfusion. During the past few decades, many neuroprotective and neurorestorative strategies have been tested in hopes of discovering improved treatment options for stroke patients, particularly patients who are not eligible for reperfusion therapy. Sadly, such hopes have not yet been fulfilled, and thus, patients are still in dire need of new stroke therapies as well as increased vigilance for amelioration of risk factors.