中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (7): 1429-1430.doi: 10.4103/1673-5374.301007

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

旁分泌因子维持神经元活力:内皮祖细胞分泌基因组的新机会

  

  • 出版日期:2021-07-15 发布日期:2021-01-07

Sustained neuronal viability by paracrine factors: new opportunities for endothelial progenitor cell secretome

Stefano Di Santo*, Hans Rudolf Widmer*   

  1. Department of Neurosurgery, Neurocenter and Regenerative Neuroscience Cluster, University Hospital Bern, Switzerland University of Bern, Inselspital, Switzerland
  • Online:2021-07-15 Published:2021-01-07
  • Contact: Stefano Di Santo, PhD, stefano.disanto@insel.ch; Hans Rudolf Widmer, PhD, hanswi@insel.ch.
  • Supported by:
    We thank Bettina Rotzetter for carefully editing the manuscript.

    This work was supported by the HANELA Foundation and the Swiss National Sci-ence Foundation (No. 31003A_135565 and 406340_128124). 

摘要: https://orcid.org/0000-0002-4032-999X 
(Stefano Di Santo);
https://orcid.org/0000-0003-3378-8765 
(Hans Rudolf Widmer)

Abstract: Despite the big progresses in the field of regenerative medicine, the loss of neurons remains essentially an unresolved challenge. Among the different approaches under investigation, there are great expectations on stem and progenitor cells-based strategies. Due to their capacity to home to the site of injury and theoretically generate all kinds of neuronal cells, stem cells seem the ideal candidates for targeted therapeutic interventions also in light of the lack of spontaneous regeneration of  the central nervous system. Unfortunately, the substantial failure to replace dead or dysfunctional cells has limited the development of stem cells-based therapies. This aspect is especially evident for the central nervous system due to the complex architecture of the tissue, the inherent fragility of mature neurons and the lack of methods to control and guide the proliferation and differentiation of neuronal precursors. However, there is compelling evidence that stem and progenitor cells are able to support different healing processes by means of paracrine actions. Taking advantage of these characteristics, researchers have investigated the cyto-protective and restorative activities of the factors released by in vitro cultured stem cells in the form of conditioned medium (CM).