中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (7): 1448-1448.doi: 10.4103/1673-5374.301037

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后门侵入:逆毒性可以解释肌萎缩性侧索硬化中定向运动神经元死亡

  

  • 出版日期:2021-07-15 发布日期:2021-01-07

Backdoor intrusion: retrotoxicity can explain targeted motor neuron death in amyotrophic lateral sclerosis 

Randall D. McKinnon*   

  1. Department of Neurosurgery and Member, The Cancer Institute of New Jersey, Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ, USA 
  • Online:2021-07-15 Published:2021-01-07
  • Contact: Randall D. McKinnon, PhD, mckinnon@rwjms.rutgers.edu.
  • Supported by:
    Supported by the New Jersey Commission on Spinal Cord Research. 

摘要: https://orcid.org/0000-0002-7539-9613
(Randall D. McKinnon) 

Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal disease of unknown cause that selectively targets brain and spinal cord motor neurons (MNs). The lifetime risk is 1 in 2000, and most cases are sporadic although up to 10% of patients are predisposed by familial mutations in MN protection or repair genes (Bruijn et al., 2004). Risk factors include agrochemical exposure and trauma (Walters et al., 2019), although why they target MN is perplexing. Farmers are at a greater risk than non-farming rural residents (Kang et al, 2014), and ALS clusters occur in abrasion prone activities conducted on agrochemical treated fields such as baseball and soccer (Chio et al., 2005). These observations suggest that one mechanism for targeted loss of MNs may be the retrograde transport of neurotoxins subsequent to peripheral nerve injury, a process termed ‘retrotoxicity’.