中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (7): 1404-1405.doi: 10.4103/1673-5374.301056

• 观点:退行性病与再生 • 上一篇    下一篇

硫酸乙酰肝素蛋白聚糖可能是诊断阿尔茨海默病的分子工具

  

  • 出版日期:2021-07-15 发布日期:2021-01-07

Heparan sulfate proteoglycans as possible diagnostic molecular tools with therapeutic potential in Alzheimer´s disease

Iván Fernández-Vega*, Laura Lorente-Gea, Carla Martín, Luis M. Quirós   

  1. Department of Pathology, Hospital Universitario Central de Asturias; Biobank of Principality of Asturias, Health Research Institute of the Principality of Asturias, Oviedo, Spain 
    (Fernández-Vega I) 
    Department of Pathology, Hospital Universitario de Araba-Txagorritxu; Biobanco Vasco para la Investigación (O+eHun), Brain Bank, Hospital Universitario, Vitoria, Spain (Fernández-Vega I, Lorente-Gea L)
    Instituto Universitario Fernández-Vega, Oviedo, Spain (Fernández-Vega I, Martín C, Quirós LM)
    Department of Functional Biology, University of Oviedo, Spain (Quirós LM) 
  • Online:2021-07-15 Published:2021-01-07
  • Contact: Iván Fernández-Vega, MD, PhD, ivan_fernandez_vega@hotmail.com

摘要: https://orcid.org/0000-0002-3141-6493
(Iván Fernández-Vega)

Abstract: Importance of dementia and Alzheimer’s disease (AD): On Earth, there is a “country” that we call Dementia with around 50 million inhabitants and an estimated global economic cost of US $1 trillion (Wimo et al., 2017). AD may contribute to 60–70% of cases, with other major forms of dementia being vascular dementia, dementia with Lewy bodies and a group of diseases that contribute to frontotemporal dementia. However, the boundaries between different forms of dementia are indistinct and mixed forms often co-exist, which are only confirmed after postmortem neuropathological studies (Fernandez-Vega et al., 2015).