中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (8): 1524-1528.doi: 10.4103/1673-5374.303010

• 综述:视神经损伤修复保护与再生 • 上一篇    下一篇

Wnt信号的视网膜神经保护作用

  

  • 出版日期:2021-08-15 发布日期:2021-01-13

The neuroprotective role of Wnt signaling in the retina

Stefan Kassumeh, Gregor R. Weber, Matthias Nobl, Siegfried G. Priglinger, Andreas Ohlmann*#br#   

  1. Department of Ophthalmology, University Hospital, LMU Munich, Mathildenstrasse 8, 80336 Munich, Germany
  • Online:2021-08-15 Published:2021-01-13
  • Contact: Andreas Ohlmann, MD, Andreas.ohlmann@med.uni-muenchen.de.
  • Supported by:
    This work was supported by the Deutsche Forschungsgemeinschaft (OH 214/4-3; FOR 1075, TP7).

摘要: https://orcid.org/0000-0002-7101-9361 (Andreas Ohlmann) 

Abstract: The canonical Wnt/β-catenin signaling pathway has been shown to play a major role during embryonic development and maturation of the central nervous system including the retina. It has a significant impact on retinal vessel formation and maturation, as well as on the establishment of synaptic structures and neuronal function in the central nervous system. Mutations in components of the Wnt/β-catenin signaling cascade may lead to severe retinal diseases, while dysregulation of Wnt signaling can contribute to disease progression. Apart from the angiogenic role of Wnt/β-catenin signaling, research in the last decades leads to the theory of a protective effect of Wnt/β-catenin signaling on damaged neurons. In this review, we focus on the neuroprotective properties of the Wnt/β-catenin pathway as well as its downstream signaling in the retina.

Key words: apoptosis, β-catenin, leukemia inhibitory factor, Müller cells, neurodegeneration, neuroprotection, Norrin, photoreceptors, retina, retinal ganglion cells, Wnt