中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (8): 1542-1543.doi: 10.4103/1673-5374.303014

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

Klotho和神经元:自噬、内质网和炎症反应的相互串扰

  

  • 出版日期:2021-08-15 发布日期:2021-01-13

Klotho and neurons: mutual crosstalk between autophagy, endoplasmic reticulum, and inflammatory response

Jennifer Mytych*   

  1. Department of Animal Physiology and Reproduction, Institute of Biology and Biotechnology, Collegium Scientarium Naturalium, University of Rzeszow, Werynia 2, 36-100 Kolbuszowa, Poland
  • Online:2021-08-15 Published:2021-01-13
  • Contact: Jennifer Mytych, PhD, jennifermytych@gmail.com or jmytych@ur.edu.pl.

摘要: https://orcid.org/0000-0002-1265-973X (Jennifer Mytych) 

Abstract: Klotho is one of a number of well-known longevity-associated genes. Its depletion in aging or disease may promote several neuropathologies associated with the central nervous system, including hypomyelination and phosphorylation of neurofilaments, synaptic loss and modulation of their plasticity, behavioral impairments, neuroinflammation, and finally neurodegeneration. Therefore, the complexity of neuronal physiology and function raises some fundamental questions about the molecular mechanisms involved in Klotho action. To date, the evidence is summarized that the common link between Klotho and neuropathological changes are perturbations in oxidative homeostasis leading to the irreversible accumulation of molecular damage in DNA, protein, and lipids fractions, and finally to cell death or senescence. However, recent studies shed more detailed light on a possible protective mechanism of Klotho in neuronal cells through modulation of endoplasmic reticulum (ER) stress pathways, autophagic process, and inflammatory reaction in response to misfolded protein accumulation.