中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (8): 1537-1538.doi: 10.4103/1673-5374.303022

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

清除抗氧化剂脱氢表雄甾酮硫酸脂类固醇的作用:秀丽隐杆线虫神经系统缺氧条件下的证据

  

  • 出版日期:2021-08-15 发布日期:2021-01-13
  • 基金资助:


Role of dehydroepiandrosterone sulfate as a scavenging antioxidant: the evidence from Caenorhabditis elegans’ nervous system under hypoxia

Leonardo Hernandez*, Gabriela Camargo   

  1. Departamento de Fisiología. CUCS-Universidad de Guadalajara, Guadalajara, Jalisco, Mexico (Hernandez L) 
    Departamento de Ciencias de la Salud. CUALTOS-Universidad de Guadalajara, Tepatitlan, Jalisco, Mexico (Camargo G)
  • Online:2021-08-15 Published:2021-01-13
  • Contact: Leonardo Hernandez, PhD,leonardo.hhernandez@academicos.udg.mx or leohhdez@hotmail.com.

摘要: https://orcid.org/0000-0002-8570-5848 (Leonardo Hernandez)

Abstract: In nature, changes in O2 levels occur frequently. An inadequate supply of oxygen often happens in living systems, which induces an imbalance between oxygen entering cells and their oxygen demand to produce energy. The condition is known as hypoxia. Although hypoxia takes place in multiple physiological processes, it can be a primary cause of cellular injury and death (Nystul and Roth, 2004). Consequently, cells and tissues are habitually at risk, and they have developed many strategies to cope with low oxygen levels leading to pathological conditions (Fawcett et al., 2015). These adaptative responses to hypoxia though not entirely understood, seem to be evolutively conserved. Notwithstanding these responses, hypoxia can still have harmful effects.